Multiplex IHC and spatial proteomic analysis reveal lamina-specific signatures in normal, Alzheimer’s and Parkinson’s disease human olfactory bulb
Helen Murray1,2, Kory Johnson2, Andrea Sedlock2, Blake Highet1, Birger Victor Dieriks1, Praju Vikas Anekal1, Richard L. M. Faull1, Maurice A. Curtis1, Alan Koretsky2, Dragan Maric2
1 University of Auckland, Auckland, New Zealand; 2National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
Published in Communications Biology 2022
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Background
![](http://multiplexihc.com/wp-content/uploads/2021/07/intro.gif)
Method
![](http://multiplexihc.com/wp-content/uploads/2021/07/methods.gif)
Results – Qualitative
![](http://multiplexihc.com/wp-content/uploads/2021/07/results1.gif)
Results – Quantitative
![](http://multiplexihc.com/wp-content/uploads/2021/07/results2.gif)
Conclusion
![](http://multiplexihc.com/wp-content/uploads/2021/07/Conclusion.gif)
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Many thanks to the Health Education Trust for funding my post-doctoral fellowship